Table 3.
Frequency of Serum Antibodies against Salmonella Typhi (Vi and O) and Salmonella Paratyphi (AO and BO) in Cases and Controls
| GBC | XGC | CC | HC | Comparisons among different groups | OR | 95% CI | *P-value among different subgroups | Overall *P-value | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | Positive No. (%) |
No. | Positive No. (%) |
No. | Positive No. (%) |
No. | Positive No. (%) |
||||||||||||||||||
| Salmonella typhi Vi antibody | |||||||||||||||||||||||||
| Male | 26 | 6 (23)a | 13 | 0 | 75 | 14 (19) | 191 | 3 (2) | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
18.8 1.3 8.6 1.9 0.16 |
4.4-81.0 0.4-3.8 0.4-165 0.0-40.7 0.0-2.8 |
< 0.001 0.63 0.06 0.65 0.09 |
< 0.001 | ||||||||||||
| Female | 74 | 7 (9) | 11 | 2 (18) | 124 | 16 (13) | 9 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
2.1 0.7 0.5 5.0 1.5 |
0.1-40.1 0.3-1.8 0.1-2.6 0.2-118.7 0.3-7.6 |
0.33 0.48 0.38 0.18 0.61 |
0.54 | ||||||||||||
| Total | 100 | 13 (13)a | 24 | 2 (8)b | 200 | 30 (15) | 200 | 3 (2) | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
9.8 0.8 1.6 5.9 0.5 |
2.7-35.3 0.4-1.7 0.3-7.8 0.9-37.7 0.1-2.3 |
< 0.001 0.64 0.53 0.03 0.38 |
< 0.001 | ||||||||||||
| Salmonella typhi O antibody | |||||||||||||||||||||||||
| Male | 26 | 3 (12)a,c | 13 | 1 (8) | 75 | 1 (1) | 191 | 2 (1) | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
12.3 9.7 1.6 7.9 6.2 |
1.9-77.7 0.9-97.4 0.1-16.7 0.7-93.1 0.4-105 |
0.001 0.02 0.71 0.054 0.15 |
0.004 | ||||||||||||
| Female | 74 | 5 (7) | 11 | 1 (9) | 125 | 6 (5) | 9 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
1.5 1.4 0.7 2.7 1.9 |
0.1-29.4 0.4-4.9 0.1-6.9 0.1-75.1 0.2-18.2 |
0.42 0.56 0.78 0.35 0.54 |
0.75 | ||||||||||||
| Total | 100 | 8 (8)a | 24 | 2 (8)b | 200 | 7 (3) | 200 | 2 (1) | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
8.6 2.3 0.9 9.0 2.5 |
1.7-41.3 0.8-6.8 0.2-4.8 1.2-67.1 0.4-12.8 |
0.001 0.09 0.96 0.01 0.25 |
0.012 | ||||||||||||
| O antibody for Salmonella paratyphi A | |||||||||||||||||||||||||
| Male | 26 | 2 (8)a | 13 | 2 (15) b | 75 | 10 (13) | 191 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
39.1 0.5 0.5 83.3 1.2 |
1.8-838 0.1-2.7 0.1-3.7 3.8-1839 0.2-6.1 |
0.001 0.44 0.45 <0.001 0.84 |
< 0.001 | ||||||||||||
| GBC | XGC | CC | HC | Comparisons among different groups | OR | 95% CI | *P-value among different subgroups | Overall *P-value | |||||||||||||||||
| No. | Positive No. (%) | No. | Positive No. (%) | No. | Positive No. (%) | No. | Positive No. (%) | ||||||||||||||||||
| O antibody for Salmonella paratyphi A | |||||||||||||||||||||||||
| Female | 74 | 4 (5) | 11 | 0 | 125 | 10 (8) | 9 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
1.2 0.7 1.5 NA 0.48 |
0.1-24.4 0.2-2.2 0.0-29.1 NA 0.0-8.7 |
0.47 0.49 0.43 NA 0.33 |
0.57 | ||||||||||||
| Total | 100 | 6 (6)a | 24 | 2 (8)b | 200 | 20 (10) | 200 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
27.5 0.5 0.7 44.5 0.8 |
1.5-495 0.2-1.4 0.1-3.7 2.0-958 0.2-3.7 |
0.001 0.24 0.68 <0.001 0.79 |
0.001 | ||||||||||||
| O antibody for Salmonella paratyphi B | |||||||||||||||||||||||||
| Male | 26 | 3 (8)a | 13 | 2 (15) b | 75 | 5 (7) | 191 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
57 1.8 0.7 83.2 2.5 |
2.9-1140 0.4-8.2 0.1-4.9 3.7-1839 0.4-14.8 |
<0.001 0.43 0.73 <0.001 0.28 |
0.001 | ||||||||||||
| Female | 74 | 1 (1) | 11 | 1 (9) | 125 | 6 (5) | 9 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
0.4 0.3 0.1 2.7 1.9 |
0.0-10.2 0.0-2.3 0.0-2.4 0.0-75.1 0.2-18.2 |
0.73 0.2 0.11 0.35 0.54 |
0.42 | ||||||||||||
| Total | 100 | 4 (4)a | 24 | 3 (12)b | 200 | 11(5) | 200 | 0 | GBC vs. HC GBC vs. CC GBC vs. XGC XGC vs. HC XGC vs. CC |
18.7 0.7 0.2 65.2 2.4 |
0.9-351 0.2-2.3 0.0-1.4 3.2-1307 0.6-9.5 |
0.004 0.57 0.1 <0.001 0.18 |
0.001 | ||||||||||||
CC, Chronic cholecystitis ; GBC, Gall bladder cancer; HC, Healthy controls ; XGC, Xanthogranulomatous cholecystitis;*Chi-square test was used; OR, Odds ratio; NA, Not applicable as there is no positive case in XGC vs. HC; aP <0.01 between GBC vs. HC; bP <0.05 between XGC vs. HC; cP <0.05 between GBC vs. CC