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. 2021 May 27;11:653607. doi: 10.3389/fonc.2021.653607

Table 4.

Critical care interventions and outcomes of the cohort assessed by NIPPV failure status.

Entire cohortn=153 NIPPV failuren=97 NIPPV successn=56 p-value
Length of vasoactive use (days) 2.0 (0.8, 8.1) 1.9 (0.7, 11.2) 3.1 (1.0, 6.3) 0.846
CRRT at any time in PICU 41 (27.0) 37 (38.1) 4 (7.3) <0.0001
Length of CRRT (days) 8.5 (3.3, 15.9) 9.1 (2.4, 15.9) 4.1 (3.8, 14.6) 0.777
Length of PICU stay (days) 10.0 (4.0, 26.0) 18.0 (7.0, 35.0) 4.0 (3.0, 7.0) <.0001
Length of NIPPV (days) 1.0 (0.4, 3.5) 0.7 (0.2, 2.3) 2.1 (0.8, 4.0) 0.0004
Length of invasive mechanical ventilation (days) 6.8 (3.0, 17.5) 6.8 (3.0, 17.5) n/a n/a
CPR 26 (17.5) 26 (27.7) 0 (0) <.0001
PICU survival 83 (54.6) 32 (33.0) 51 (92.7) <.0001
Hospital survival 66 (43.1) 27 (27.8) 39 (69.6) <.0001

Values are medians (IQRs) for continuous variables and frequencies (percentages) for categorical variables, with p-values from Wilcoxon Rank Sum and Chi-Square (Fisher’s Exact when cell counts were small) tests, respectively.

NIPPV, noninvasive positive pressure ventilation; CRRT, Continuous renal replacement therapy; PICU, Pediatric intensive care unit; CPR, cardiopulmonary resuscitation.