Table 4.

Design and results.

Run	F1 CHOL: HSPC ratio	F2 CHE drug-lipids ratio	F3 drug incubation time	Response 1 Size (nm)	Response 2 DL (%)
1	1.67	0.16	30.00	127.9	12.927
2	1.67	0.16	30.00	119	13.1154
3	1.67	0.16	30.00	137.5	11.2043
4	2.46	0.21	38.92	154	10.7668
5	3.00	0.16	30.00	240.6	9.32359
6	0.87	0.10	21.08	118.8	9.31382
7	1.67	0.16	30.00	123.1	13.7509
8	2.46	0.21	21.08	204	15.6274
9	1.67	0.16	30.00	117.8	11.8688
10	0.33	0.16	30.00	109.9	15.9702
11	1.67	0.16	45.00	143.8	7.15909
12	1.67	0.16	30.00	146.3	14.3151
13	0.87	0.21	21.08	126.7	15.7016
14	2.46	0.10	21.08	196.9	5.96926
15	1.67	0.06	30.00	125.2	3.93899
16	1.67	0.25	30.00	158.1	18.3233
17	0.87	0.10	38.92	123.4	6.77879
18	0.87	0.21	38.92	138	13.4262
19	2.46	0.10	38.92	171.7	2.79281
20	1.67	0.16	15.00	144.8	10.6013