Table 3.
Fatty acids profile (%) in serum of healthy controls (HC) and CRC patients.
| HC n=35 | CRC n=44 | p | |
|---|---|---|---|
| 10:0 | 0.021 ± 0.001 | 0.019 ± 0.006 | 0.804 |
| 12:0 | 0.25 ± 0.019 | 0.14 ± 0.016 | <0.001 |
| 14:0 | 1.20 ± 0.051 | 0.88 ± 0.059 | <0.001 |
| 16:0 | 23.3 ± 0.29 | 23.3 ± 0.33 | 0.966 |
| 18:0 | 7.25 ± 0.12 | 6.88 ± 0.16 | 0.073 |
| 20:0 | 0.078 ± 0.004 | 0.088 ± 0.005 | 0.113 |
| 22:0 | 0.15 ± 0.008 | 0.17 ± 0.009 | 0.151 |
| 24:0 | 0.14 ± 0.006 | 0.14 ± 0.009 | 0.906 |
| 26:0 | traces | 0.020 ± 0.007 | – |
| 28:0 | ND | traces | – |
| Total ECFA | 32.4 ± 0.31 | 31.7 ± 0.32 | 0.103 |
| 11:0 | 0.013 ± 0.001 | 0.005 ± 0.001 | <0.001 |
| 13:0 | 0.027 ± 0.002 | 0.012 ± 0.002 | <0.001 |
| 15:0 | 0.23 ± 0.009 | 0.23 ± 0.010 | 0.768 |
| 17:0 | 0.25 ± 0.007 | 0.25 ± 0.008 | 0.954 |
| 19:0 | 0.031 ± 0.002 | 0.019 ± 0.002 | <0.001 |
| 21:0 | 0.014 ± 0.001 | 0.013 ± 0.001 | 0.395 |
| 23:0 | 0.056 ± 0.003 | 0.050 ± 0.004 | 0.190 |
| Total OCFA | 0.63 ± 0.017 | 0.58 ± 0.021 | 0.093 |
| 13-methyl-14:0 | 0.031 ± 0.002 | 0.020 ± 0.002 | <0.001 |
| 14-methyl-15:0 | 0.073 ± 0.003 | 0.054 ± 0.007 | 0.014 |
| other iso-BCFA | 0.13 ± 0.007 | 0.13 ± 0.008 | 0.717 |
| Total iso BCFA | 0.24 ± 0.011 | 0.20 ± 0.014 | 0.063 |
| 12-methyl-14:0 | 0.046 ± 0.002 | 0.032 ± 0.004 | 0.002 |
| 14-methyl-16:0 | 0.12 ± 0.007 | 0.067 ± 0.004 | <0.001 |
| 20-methyl-22:0 | 0.003 ± 0.000 | 0.005 ± 0.001 | 0.061 |
| Total anteiso BCFA | 0.17 ± 0.008 | 0.10 ± 0.008 | <0.001 |
| Total SFA | 33.5 ± 0.30 | 32.6 ± 0.34 | 0.054 |
| 14:1 | 0.075 ± 0.005 | 0.039 ± 0.004 | <0.001 |
| 16:1 | 3.11 ± 0.16 | 3.02 ± 0.13 | 0.669 |
| 18:1 | 27.0 ± 0.50 | 29.2 ± 0.43 | 0.001 |
| 19:1 | 0.027 ± 0.002 | 0.021 ± 0.003 | 0.059 |
| 20:1 | 0.17 ± 0.007 | 0.16 ± 0.008 | 0.145 |
| 22:1 | 0.034 ± 0.004 | 0.021 ± 0.003 | 0.006 |
| 24:1 | 0.23 ± 0.017 | 0.24 ± 0.015 | 0.689 |
| 26:1 | ND | 0.001 ± 0.000 | – |
| Total MUFA | 30.6 ± 0.57 | 32.7 ± 0.49 | 0.007 |
| CPOA2H | 0.17 ± 0.005 | 0.11 ± 0.006 | <0.001 |
| ALA | 0.34 ± 0.018 | 0.23 ± 0.017 | <0.001 |
| EPA | 1.08 ± 0.13 | 0.87 ± 0.060 | 0.153 |
| DHA | 1.14 ± 0.076 | 1.43 ± 0.077 | 0.011 |
| other PUFAn-3 | 0.39 ± 0.010 | 0.41 ± 0.016 | 0.301 |
| Total PUFAn-3 | 2.95 ± 0.20 | 2.94 ± 0.14 | 0.963 |
| LA | 25.7 ± 0.61 | 24.2 ± 0.55 | 0.077 |
| DGLA | 1.16 ± 0.039 | 1.15 ± 0.056 | 0.821 |
| ARA | 5.60 ± 0.20 | 6.00 ± 0.211 | 0.175 |
| AdA | 0.10 ± 0.005 | 0.12 ± 0.014 | 0.134 |
| other PUFAn-6 | 0.23 ± 0.008 | 0.19 ± 0.008 | <0.001 |
| Total PUFAn-6 | 32.8 ± 0.63 | 31.7 ± 0.63 | 0.217 |
Values are mean ± SEM. ND, not detected. AdA, adrenic acid (22:4 n-6); ALA, linolenic acid (18:3 n-3); ARA, arachidonic acid (20:4 n-6); BCFA, branched chain fatty acids; CPOA2H, cyclopropaneoctanoic acid 2-hexyl; DGLA, dihomo–linolenic acid (20:3 n-6); DHA, docosahexaenoic acid (22:6 n-3); DPA, docosapentaenoic acid (22:5 n-3); ECFA, even chain fatty acids; EPA, eicosapentaenoic acid (20:5 n-3); LA, linoleic acid (18:2 n-6); MUFA, monounsaturated fatty acids, OCFA, odd chain fatty acids; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids. Bold represents main groups of fatty acids.