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. 2021 May 27;11:601668. doi: 10.3389/fonc.2021.601668

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Copyright © 2021 Lei, Wang, Sun, Fu, Tian, Yang, Wang and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nanog⁺ CTC expression is positively correlated with recurrence (A) CTC number, (B) Nanog count, (C) The higher the expression of Mixed CTC number and Nanog, the higher the early recurrence rate of liver cancer; (D) Kaplan–Meier estimates of disease-free survival (E) (p<0.001) and overall (F) (p<0.001) survival of 160 HCC patients with high-level Nanog (≥500 μm2/field) and low-level Nanog (< 500 μm2/field).