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. 2021 May 27;12:684344. doi: 10.3389/fimmu.2021.684344

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Copyright © 2021 Kim, Park, Park and Hoe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pretreatment of sorafenib decreases LPS-mediated AKT and STAT3 phosphorylation in wild-type mice. (A, C) Immunofluorescence staining with anti-p-AKT^S473 and anti-p- STAT3^S727 antibody of brain slices from wild-type mice treated with sorafenib followed by LPS. (B, D) Quantification of the data in (A, C) (analyzed number of brain slices/images (n); p-AKT ^S473: Vehicle, n =16; LPS, n=16; Sorafenib + LPS, n=14, p-STAT3 ^S727, Vehicle, n=23; LPS, n=22; Sorafenib + LPS, n=20). *p < 0.05, **p < 0.01, Scale bar = 200 μM.