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. 2021 May 27;11:687594. doi: 10.3389/fonc.2021.687594

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Copyright © 2021 Zampedri, Martínez-Flores and Melendez-Zajgla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Workflow of zAVATARS in the context of personalized medicine. (A–C) Experimental setup for generating zebrafish xenotransplant models. Cells derived from itumor biopsy are analyzed by RNAseq, subsequently labeled and microinjected in the 2dpf larvae. (D) One day after injection, larvae are screened for successful injection and distributed in groups for testing chemo-, and/or biological therapies. (E) Three days after treatment, larvae are processed for in vivo microscopy for analysis of proliferation, cell death, angiogenesis, and metastatic potential. (F) Treatment decision of breast cancer patients based on response of zebrafish cancer hallmarks in drug screening. hpf: hours post fertilization. dpi: days post injection. BRCA zPDX trials: Trial of patient-derived xenotransplants in zebrafish for the study of breast cancer.