Table 2.
Functional relationship between conserved lncRNAs and breast cancer hallmarks.
| Zebrafish name | Human lncRNA name | lncRNA type | Activate | Inhibited | O or S | Expression |
|---|---|---|---|---|---|---|
| ZFLNCT16634 (LOC103909273 un-characterized) | DLX6-AS1 | Antisense | P, I, EMT, Mi, T | Ap, CellC, D, DNAd, DNAr, H, Inf, Q | O | Up-regulated |
| ZFLNCT02505 (ENSDART00000153684.2, CR751227.1-201) | HAGLR (HOXD-AS1) | Antisense, | An, D, Inf, Me | DNA r, I, Q | O | _ |
| ZFLNCT08532 (NONDRET012204.1) | HOTAIR | Antisense, lincRNA | D, Mi, Me, I, T | DNAr, EMT, I, Ap | O | Up-regulated |
| ZFLNCT02498 (ENSDART00000155072.3, ENSDART00000155419.2, ENSDART00000155896.2, LOC103910246) | HOXA11-AS | Antisense, sponge | CellC, Inf, Q, P, I, Me, Mi | DNAd, DNAr, I, Ap | O/S in OC | Up-regulated |
| HOXA-AS2 | Antisense, ceRNA, sponge | Ch, P, I, Mi, T, Prog, EMT | D, Ap | O | – | |
| HOXA-AS3 | Antisense, sponge | P, Mi, I, S, Me | EMT, Inf, Me, An, Ap | O | Up-regulated | |
| HOXB-AS1 | Antisense, ceRNA | P, CellC, I, Mi | Ap | O | Up-regulated | |
| ZFLNCT19656 (si:dkey-81p22.11) | HOXC-AS3 | Sponge | P, H, T, I, Mi, Me | Q | O | Up-regulated |
| ZFLNCT01281 | LINC00649 | Antisense | An, Ap, cellC, D, EMT, H, I, Me, P, Q | _ | Down-regulated | |
| ZFLNCT17432 (ENSDART00000153409.2) | LINC00324 | lincRNA | P, I, Me, Mi, S | Ap | O | Up-regulated |
| ZFLNCT14004 (ENSDART00000149569.3) | LINC00461 | lincRNA, ceRNA, Sponge | P, cellC, DNAd, S, Mi, I, Me, T, EMT | An, H, Q, Ap | O | Up-regulated |
| ZFLNCT12716 (lnc2_zgc:194285, lnc1_zgc:194285) | MALAT1 | Sponge, ceRNA, lincRNA | Mi, I, EMT, An, H, S, P, Me, Ap | An, CellC, DNAd, DNAr, EMT, Inf, I, Me, Q, P | O and S | _ |
| ZFLNCT01941 (lnc_ghrhra) | MAPT-AS1 | Antisense | CellC, S. In ER negative BRCA induce P and Mi. | Ap, DNAd, DNAr, EMT, H, I, Me, P, Q | S | _ |
| ZFLNCT11804 (oip5-as1-202, Cyrano) | OIP5-AS1 (Linc-OIP5, Cyrano) | ceRNA | P, Mi, I, T, CellC, DNAd, S, Me, EMT | P, RR (CRC) | O ans S | Up-regulated |
| ZFLNCT11748 (NONDRET002400.1) | PAX8-AS1 | Processed transcript | Ap | Ap, CellC, DNAd, DNAr, H, Inf, I, Me, P, Q, S | S | Down-regulated |
| ZFLNCT19020 (PF102167.1-201, ENSDART00000149948.3, sox2ot, si:ch73-334e23.1, LOC101883930) | SOX2-OT | Sense overlapping | P, I, Me | Ap, CellC, D, DNAd, DNAr, H, Q | O | Up-regulated |
| ZFLNCT09180 (BX571737.1-201) | TTN-AS1 | Antisense, ceRNA, sponge, lincRNA | DNAd, P and Me in ESCC. P, I, EMT and Mi in BRCA and CRC | Ap, CellC, DNAd, DNAr, EMT, H, Inf, I, Me | O | Up-regulated |
| PTENP1 | PTENP1 | ceRNA, sponge | Ap | Mi, P, I | S | Down-regulated |
P, proliferation; An, angiogenesis; Me, metastasis; CellC, Cell cycle; D, differentiation; DNAd, DNA damage; H, Hypoxia; Inf, Inflamation; Q, quiescence; I, Invasion; Mi, Migration; EMT, Epithelial-Mesenchymal transition; T, Tumorigenesis; S, Stemness; Ch, Chemoresitance; Prog, Progression; DR, Drug resistance; RR, Radio resistance; BRCA, Breast cancer; O, oncogenic roll; S, Tumor suppressor roll.