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. 2020 Nov 9;7(3):mgen000472. doi: 10.1099/mgen.0.000472

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© 2021 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License.

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Fig. 7. — Organization of the (a) bile and (b) oxidative stress resistance genes in Lactobacillacea e plasmids. Numbers on the right side of the clusters indicate the number of plasmids showing that type of arrangement of the cluster. The bile resistance genes (a) were: bsh, choloylglycine hydrolase; phosphatase, protein tyrosine/serine phosphatase; RR, two-component response regulator; HPK, signal transduction histidine kinase; permease, ABC transporter permease protein; and transporter, ABC-type multidrug transport system ATPase component. The bile resistance genes were from L. salivarius UCC118 (CP000234.1), L. salivarius CECT 5713 (CP002037.1), L. salivarius JCM1046 (CP007647.1), L. salivarius str. Ren (CP011404.1), L. salivarius CICC 23174 (CP017108.1), L. salivarius ZLS006 (CP020859.1), L. salivarius BCRC 12574 (CP024065.1), L. salivarius BCRC 14759 (CP024068.1). The oxidative stress resistance genes (b) were: arsR, transcriptional regulator; trxA, thioredoxin; trxB, thioredoxin reductase; frnE, disulfide isomerase; and gshR, glutathione reductase. The oxidative stress resistance genes were from, group 1: L. plantarum LP3 (CP017068.1), L. plantarum CAUH2 (–) (CP015129.2), L. brevis LMT1-73 (CP033887.1), L. plantarum LMT1-48 (CP033892.1), L. brevis SRCM101174 (CP021481.1), L. brevis 100D8 (CP015340.1), L. brevis KB290 (–) (AP012172.1), L. brevis SRCM101106 (CP021676.1), L. plantarum ATG-K2 (–) (CP032463.1), L. plantarum DSR M2 (CP022293.1), L. sakei WiKim0063 (CP022710.1), L. sakei WiKim0072 (–) (CP025138.1), L. sakei WiKim0074 (CP025207.1); group 2: L. plantarum ZFM55 (CP032360.1), L. plantarum ZFM9 (CP032643.1), L. plantarum SRCM102022 (CP021502.1), L. plantarum KACC 92189 (CP024060.1).