Table 1.
LESB58 genes in the UK LES population inferred to have independently acquired nonsense mutations four or more times
|
No. of independent acquisitions |
Gene name |
No. of genomes |
Gene description |
|---|---|---|---|
|
32 |
oprD |
51 |
Imipenem outer-membrane porin |
|
18 |
lasR |
26 |
Transcriptional regulator of quorum sensing |
|
21 |
mexB |
43 |
Multidrug efflux pump transporter, part of the mexAB-oprM operon |
|
20 |
PLES_59241 |
32 |
Hypothetical membrane protein |
|
13 |
mucA |
29 |
Anti-sigma factor for alginate biosynthesis |
|
10 |
glpT |
15 |
Sn-glycerol-3-phosphate transporter |
|
9 |
mltD |
55 |
Murein transglycosylase D precursor |
|
8 |
pncA |
10 |
Nicotinamidase |
|
7 |
PLES_34011 |
13 |
TonB-dependent receptor |
|
6 |
PLES_48481 |
16 |
Hypothetical protein |
|
6 |
pmrB |
6 |
Two-component regulator system |
|
5 |
PLES_46251 |
12 |
Putative glycosyl transferase |
|
5 |
opmQ |
7 |
Putative outer-membrane protein precursor |
|
5 |
PLES_16021 |
5 |
Transcriptional regulator (marR orthologue, involved in repression of MDR mar operon) |
|
5 |
mpl |
11 |
UDP-N-acetylmuramate:L-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase |
|
5 |
chpA |
5 |
Chemosensory system component |
|
5 |
PLES_51581 |
5 |
Putative S-adenosylmethionine decaboxylase proenzyme |
|
5 |
mdoH |
13 |
Glucosyltransferase involved in biofilm formation |
|
5 |
ampD |
111 |
N-acetyl-anhydromuranmyl-l-alanine amidase |
|
4 |
PLES_46401 |
101 |
Hypothetical protein with filamentous haemagglutinin outer-membrane domain) |
|
4 |
PLES_03151 |
9 |
Transcriptional regulator |
|
4 |
PLES_47771 |
8 |
Two-component sensor |
|
4 |
pchE |
7 |
Dihydroaeruginoic acid synthase |
|
4 |
mexA |
7 |
Multidrug efflux pump transporter, part of the mexAB-oprM operon |
|
4 |
PLES_07571 |
5 |
Putative oxidoreductase |
|
4 |
PLES_29121 |
7 |
Putative ATP-binding/permease fusion ABC transporter involved in sulphate metabolism |