Table 1.
Strain |
MS8413 |
MS8419 |
MS8436 |
MS8442 |
MS8441 |
|
---|---|---|---|---|---|---|
Patient |
4 |
5 |
6 |
7 |
8 |
|
Site |
Leg wound |
ETA |
Tissue buttock |
Wound Swab |
Rectal Swab |
|
Colistin |
Colistin |
0.125 |
0.25 |
0.25 |
0.125 |
0.5 |
Carbapenem |
Mero |
32 |
>32 |
>32 |
>32 |
>32 |
Imi |
>32 |
>32 |
n.t |
>32 |
n.t |
|
Erta |
>32 |
>32 |
>32 |
>32 |
>32 |
|
Beta-lactam and Cephalosporins |
Sulb |
32 |
32 |
64 |
32 |
64 |
MER |
R |
R |
R |
R |
R |
|
TIM |
R |
R |
R |
R |
R |
|
TAZ |
R |
R |
R |
R |
R |
|
CRO |
R |
R |
R |
R |
R |
|
CAZ |
R |
R |
R |
R |
R |
|
FEP |
R |
R |
R |
R |
R |
|
KZ |
R |
R |
R |
R |
R |
|
Azt |
6 mm R |
6 mm R |
n.t |
6 mm R |
n.t |
|
CTZ/TAZ |
>256 |
>256 |
128 |
16 |
96 |
|
CAZ/AVI |
16 mm R |
17 mm R |
18 mm R |
15 mm R |
18 mm R |
|
blaADC-25 |
+ |
+ |
+ |
+ |
+ |
|
blaOXA-23 |
+ |
+ |
+ |
+ |
+ |
|
blaOXA-66 |
+ |
+ |
+ |
+ |
+ |
|
Aminoglycosides |
Amikacin |
>256 |
>256 |
>256 |
>256 |
>256 |
GENT |
R |
R |
R |
R |
R |
|
TOB |
R |
R |
R |
R |
R |
|
Aph(3′)-Ic-1 |
+ |
+ |
+ |
+ |
+ |
|
aadA1 |
+ |
+ |
+ |
+ |
+ |
|
armA |
+ |
+ |
+ |
+ |
+ |
|
Quinolones |
CIP |
R |
R |
R |
R |
R |
NOR |
R |
R |
R |
R |
R |
|
Trimmethoprim/ Sulphonamide |
TMP |
R |
R |
R |
R |
R |
SXT |
R |
R |
R |
R |
R |
|
Sul1 |
+ |
+ |
+ |
+ |
+ |
|
Sul2 |
+ |
+ |
+ |
+ |
+ |
|
Tigecycline |
Tige |
2 |
2 |
2 |
2 |
4 |
Chloramphenicol |
Chloro |
6 mm R |
6 mm R |
n.t |
6 mm R |
n.t |
catB8 |
+ |
+ |
+ |
+ |
+ |
|
Fosfomycin |
Fosfo |
256 |
512 |
n.t |
128 |
n.t |
Tetracycline |
Doxy |
4 |
4 |
2 |
2 |
2 |
Macrolides |
mph(E)_3 |
+ |
+ |
+ |
+ |
+ |
msr(E)_4 |
+ |
+ |
+ |
+ |
+ |
|
Streptomycin |
strA |
+ |
+ |
+ |
+ |
+ |
strB |
+ |
+ |
+ |
+ |
+ |
n.t, not tested; Mero, Meropenem; Tige, Tigecycline; Sulb, Sulbactam; CTZ/TAZ, Ceftolozane/tazobactam; CAZ/AVI, Ceftazidime/avibactam; Chloro, Chloramphenicol; Fosfo, Fosfomycin; Azt, Aztreonam; Erta, Ertapenem; Doxy, Doxycycline; Imi, Imipenem; KZ, Cephazolin; TMP, Trimethoprim; SXT, Co-trimoxazole; GENT, Gentamicin; TOB, Tobramycin; CRO, Ceftriaxone; CAZ, Ceftazidime; FEP, Cefepime; TAZ, Piperacillin/tazobactam; CIP, Ciprofloxacin; NOR, Norfloxacin; MER, Meropenem; TIM, Ticarcillin/clavulanate.