Table 3.

Selection of P. aeruginosa intergenic regions under positive selection

Mutations in intergenic regions were identified as positively selected by Khademi et al. [81] and selected for this table according to their number, the number of affected lineages and the number of longitudinal studies highlighting mutations in the same intergenic region. The complete list is shown in Table S1.

Upstream/downstream genes		Upstream/ downstream PAO1 locus		Upstream/downstream products	No. of intergenic mutations	No. of lineages	Reference
phuS // phuR		PA4709 // PA4710		PhuS/haem/haemoglobin uptake outer-membrane receptor	40	4	[7, 9, 18, 81]
PA0428 // PA0429		PA0428 // PA0429		Probable ATP-dependent RNA helicase/hypothetical protein	34	10	[81]
PA4786 // PA4787		PA4786 // PA4787		Probable short-chain dehydrogenase/probable transcriptional regulator	28	12	[81]
PA4690.5 // PA4691		PA4690.5 // PA4691		16S ribosomal RNA/hypothetical protein	54	6	[81]
PA2535 // PA2536		PA2535 // PA2536		Probable oxidoreductase/probable phosphatidate cytidylyltransferase	18	6	[7, 81]
motY // pyrC		PA3526 // PA3527		Probable outer-membrane protein precursor/dihydroorotase	32	6	[81]
PA3230 // PA3231		PA3230 // PA3231		Conserved hypothetical protein/conserved hypothetical protein	24	7	[81]
algL // algl		PA3547 // PA3548		Poly(β-d-mannuronate) lyase precursor/alginate O-acetyltransferase	14	6	[7, 81]
PA0976.1 // PA0977		PA0976.1 // PA0977		tRNA-Lys/hypothetical protein	26	6	[81]
rplU // ispB		PA4568 // PA4569		50S ribosomal protein L21/octaprenyldiphosphate synthase	22	7	[81]
phzM // phzA1		PA4209 // PA4210		Probable phenazine-specific methyltransferase	12	6	[7, 81]
oprO // PA3281		PA3280 // PA3281		Pyrophosphate-specific outer-membrane porin precursor/hypothetical protein	10	5	[7, 81]
ldh // PA3419		PA3418 // PA3419		Leucine dehydrogenase	10	5	[7, 81]
ampR // ampC		PA4109 // PA4110		Transcriptional regulator/β-lactamase precursor	12	4	[9, 81]
PA5160.1 // rmlB		PA5160.1 // PA5161		tRNA-Thr/dTDP-d-glucose 4,6- dehydratase	16	6	[81]

Genes of which the promoter is located in the impacted intergenic region are underlined.