Figure 5:

Correlogram between baseline and delta imaging biomarkers.

Correlation between pretreatment imaging biomarkers: FDG uptake of tumor, bone marrow, spleen (SUV), metabolic tumor burden (PTV, TLP), HISUV and metabolic proliferative biomarkers in hematopoietic tissues (BLR, SLR). Spearman’s correlation coefficients were used. The strength of each statistically significant correlation is displayed using a color code and the size of the circle. Clusters are performed using an unsupervised approach.

A. Per patient analysis (n=5 pts)

B. Per lesion analysis including PET at 6 weeks (n=13 lesions)

C. Per lesion analysis including PET at 6 weeks and CT at 12 weeks (n=8 lesions)