Table 4.
Compositional data, intake values, reference points and margin of exposure (MOE) for the individual components of expressed mandarin oil classified according to assessment groups
| Essential oil composition | Exposure | Hazard characterisation | Risk characterisation | |||||
|---|---|---|---|---|---|---|---|---|
| Assessment group | FLAVIS no | Max conc. in the oil | Max feed conc. | Intakea | Cramer class | NOAELb | MOE | MOET |
| Constituent | – | % | mg/kg | mg/kg bw per day | – | mg/kg bw per day | – | – |
| CG 1 | ||||||||
| Octanal | 05.009 | 0.22 | 0.0330 | 0.0030 | I | 120 | 40,506 | |
| CG 3 | ||||||||
| α‐Sinensal | 05.130 | 0.84 | 0.125 | 0.0112 | I | 3 | 267 | |
| CG 6 | ||||||||
| Linalool | 02.013 | 0.53 | 0.080 | 0.0071 | I | 117 | 35029 | |
| α‐Terpineol | 02.097 | 0.26 | 0.039 | 0.0035 | I | 250 | 33677 | |
| MOET CG 6 | 0.0093 | 17,170 | ||||||
| CG 8 | ||||||||
| Fenchone | n.a. | 0.03 | 0.005 | 0.0004 | II | 0.91 | 2,253 | |
| l‐Camphor | n.a. | 0.01 | 0.002 | 0.0001 | II | 0.91 | 6,143 | |
| MOET CG 8 | 0.0005 | 1,648 | ||||||
| CG 13 | ||||||||
| cis‐Linalool oxide | n.a. | 0.08 | 0.011 | 0.0010 | II | 0.91 | 901 | |
| CG 25 | ||||||||
| Thymol | 04.006 | 0.37 | 0.055 | 0.0049 | I | 36 | 7,285 | |
| CG 27 | ||||||||
| Methyl N‐methylanthranilate | 09.781 | 1.59 | 0.238 | 0.0214 | I | 20 | 936 | |
| CG 31, II (Acyclic alkanes) | ||||||||
| Myrcene | 01.008 | 2.11 | 0.348 | 0.0312 | I | 44 | 1,408 | |
| α‐Farnesene | 01.040 | 0.11 | 0.104 | 0.0093 | I | 44 | 4,722 | |
| MOET CG 31, II | 0.0406 | 1,085 | ||||||
| CG 31, III (Cyclohexene hydrocarbons) | ||||||||
| Limonene | 01.045 | 68.6 | 10.29 | 0.9238 | I | 250 | 271 | |
| γ‐Terpinene | 01.020 | 24.7 | 3.705 | 0.3326 | I | 250 | 752 | |
| Terpinolene | 01.005 | 1.49 | 0.223 | 0.0200 | I | 250 | 12,477 | |
| α‐Terpinene | 01.019 | 0.76 | 0.115 | 0.0103 | I | 250 | 24,300 | |
| β‐Phellandrene | 01.055 | 0.43 | 0.065 | 0.0058 | I | 250 | 42,876 | |
| MOET CG 31, III | 1.2925 | 193 | ||||||
| CG 31, IVe (Benzene hydrocarbons, alkyl) | ||||||||
| p‐Cymene | 01.002 | 0.80 | 0.120 | 0.0108 | I | 154 | 14,154 | |
| CG 31, V (Bi‐, tricyclic, non aromatic hydrocarbons) | ||||||||
| α‐Pinene | 01.004 | 4.51 | 0.677 | 0.0607 | I | 222 | 3,655 | |
| β‐Pinene | 01.003 | 2.31 | 0.347 | 0.0311 | I | 222 | 7,137 | |
| Sabinene | 01.059 | 0.88 | 0.133 | 0.0119 | I | 222 | 18,649 | |
| MOET CG 31, V | 0.1037 | 2,140 | ||||||
| CG 31, VI (macrocyclic non aromatic hydrocarbons) | ||||||||
| 3,7,10‐Humulatriene | 01.043 | 0.03 | 0.004 | 0.0004 | I | 3 | 8,569 | |
| CG 32 (epoxides) | ||||||||
| cis‐Limonene epoxide | n.a. | 0.02 | 0.002 | 0.0002 | I | 3 | 13,924 | |
| trans‐Limonene epoxide | n.a. | 0.01 | 0.001 | 0.0001 | I | 3 | 24,754 | |
| MOET CG 32 | 0.0012 | 8,911 | ||||||
CG: chemical group; bw: body weight.
Intake calculations for the individual components are based on the use level of 15 mg/kg in feed for chicken for fattening, the species with the highest ratio of feed intake/body weight. The MOE for each component is calculated as the ratio of the reference point (NOAEL) to the intake. The combined margin of exposure (MOET) is calculated for each assessment group as the reciprocal of the sum of the reciprocals of the MOE of the individual substances.
Values in bold refer to those components for which the NOAEL value was available, values in italics are the 5th percentile of the distribution of NOAELs of the corresponding Cramer Class, other values (plain text) are NOAELs extrapolated by using read‐across.