Fig. 6. 2-E channel inhibitor protects mice against SARS-CoV-2 infection and limits inflammation in the lung.

a Scheme of experimental parameters. The dose of SARS-CoV-2 was 2 × 10⁶ TCID₅₀ per mouse. b Body (Left), lung and spleen (Right) weight after infection with SARS-CoV-2 and injection with BE-33. c Viral RNA loading of different parts of mouse lungs after infection with SARS-CoV-2 and injection with BE-33. d Lesions in the lungs and spleens. A view of the ventral lungs and spleens of an infected animal obtained at necropsy post infection (left) (Scale bars, 2.5 mm). The pathology score was on the right. e H&E staining of lung sections (Scale bars, 50 μm). Each image is representative of a group of 3 mice. f Left lungs of each group were evaluated for cytokine and chemokine expression by qRT-PCR assay. n > 5 for each group, and mice were killed at different time as indicated. *P < 0.05; **P < 0.01; ***P < 0.001; Student’s t-test. All error bars are SEM.