Table 3. pK*b and Coefficient m Values for 4,6-Dihydroxypyrimidine Derivatives.
| compound | pK*b1 | m | pK*b2 | m | pK*b3 | m |
|---|---|---|---|---|---|---|
| Ho | ||||||
| 1 | 0.18 ± 0.01 | 1.06 ± 0.04 | –2.84 ± 0.22 | 0.45 ± 0.04 | ||
| 2 | –0.32 ± 0.02 | 0.79 ± 0.02 | –2.91 ± 0.15 | 0.41 ± 0.03 | ||
| 3 | –2.09 ± 0.08 | 2.31 ± 0.07 | –4.14 ± 0.03 | 1.15 ± 0.01 | –5.99 ± 0.35 | 0.64 ± 0.04 |
| 7 | –0.026 ± 0.037 | 0.94 ± 0.05 | –2.81 ± 0.17 | 0.48 ± 0.03 | ||
| 8 | –2.76 ± 0.11 | 0.46 ± 0.02 | ||||
| 9 | –3.02 ± 0.41 | 0.51 ± 0.07 | ||||
| Ha | ||||||
| 1 | 0.00 ± 0.01 | 1.32 ± 0.05 | –3.68 ± 0.21 | 0.94 ± 0.06 | ||
| 2 | –0.47 ± 0.04 | 1.02 ± 0.03 | –3.67 ± 0.25 | 0.84 ± 0.07 | ||
| 3 | –2.49 ± 0.09 | 2.90 ± 0.09 | –5.32 ± 0.21 | 2.022 ± 0.08 | –6.10 ± 0.04 | 1.08 ± 0.08 |
| 7 | –0.19 ± 0.04 | 1.18 ± 0.06 | –3.75 ± 0.23 | 0.99 ± 0.06 | ||
| 8 | –3.72 ± 0.08 | 0.95 ± 0.02 | ||||
| 9 | –3.41 ± 0.37 | 0.87 ± 0.10 | ||||
| HI | ||||||
| 3 | –1.85 ± 0.09 | 1.58 ± 0.06 | –4.18 ± 0.10 | 0.84 ± 0.08 | –6.64 ± 0.39 | 0.57 ± 0.04 |
| Hr | ||||||
| 3 | –1.48 ± 0.11 | 1.16 ± 0.05 | –3.70 ± 0.08 | 0.52 ± 0.01 | –6.03 ± 0.61 | 0.33 ± 0.04 |