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. 2021 Jun 9;20:115. doi: 10.1186/s12934-021-01605-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vivo bioactivity of rhIL-15, IL-15/SuIL-15Rα-dFc and IL-15/SuIL-15Rα-mFc. C57BL/6 J mice (male, 6–8 weeks of age, n = 10–14 for each group) were intravenously injected with PBS, 0.28 mg/kg rhIL-15 or 1 mg/kg IL-15/SuIL-15Rα-IgG4 Fc complexes. Seventy-two hours after treatment, spleens and blood samples were collected and prepared for flow cytometry. a Representative photo of spleens separated from each group (n = 5). b Spleen weight statistics. c The percentage of each indicated cell subset in splenocytes. d The percentage of each indicated cell subset in peripheral blood cells. The data shown in b, c, and d are combined from three independent experiments, and all data points are the means ± standard deviation. ns, not significant; *: p < 0.05; **: p < 0.01; ***: p < 0.001 and ****: p < 0.0001