Table 1.

Function of mutations in IL-15/SuIL-15Rα-IgG4 Fc complexes

Mutation	Function
IL-15
N71Q	Remove N-glycosylation modification
N72D	Increase binding affinity to human IL-15Rβ, enhance biological activity of IL-15
N79Q	Remove N-glycosylation modification
N112Q	Remove N-glycosylation modification
IgG4 Fc
L235E	Eliminate FcγR binding, reduce effector function
S228P	Prevent Fab-arm exchange, stabilize the disulfides in the core hinge
N297Q	Remove N-glycosylation modification