Table 3.

Effects of rhIL-2, rhIL-15 and IL-15/SuIL-15Rα-IgG4 Fc complexes on CD8⁺ T cell phenotypic markers

Marker	Ctrl	rhIL-2	rhIL-15	dFc	mFc
IFN-γ	1.6 ± 0.3	1.7 ± 0.4	6.5 ± 2.3	8.6 ± 4.1	8.4 ± 3.1
Granzyme B	20.7 ± 7.5	22.9 ± 8.3	24.5 ± 7.4	25.3 ± 7.7	25.4 ± 8.0
Perforin	31.8 ± 7.3	37.5 ± 7.7	40.7 ± 10.4	40.6 ± 11.9	40.1 ± 11.8
Ki67	0.9 ± 0.4	1.5 ± 0.7	2.6 ± 0.9	3.2 ± 2.1	2.5 ± 0.9

Human PBMCs from healthy donors (n = 5) were cultured for 24 h in the absence or presence of 50 IU/mL rhIL-2, 10 ng/mL rhIL-15 or 35.7 ng/mL IL-15/SuIL-15Rα-IgG4 Fc complexes, and the expression of selected markers on CD8⁺ T cells was analyzed by flow cytometry. The percentages of CD8⁺ T cells that expressed the corresponding markers are listed in the table. dFc: IL-15/SuIL-15Rα-dFc; mFc: IL-15/SuIL-15Rα-mFc