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. 2021 Feb 22;2(3):702–712. doi: 10.1039/d0cb00199f

Sequences of HS oligosaccharides described in this review.

Name Abbreviated saccharide sequence Functions
18-mer-HP GlcNS-GlcA-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-IdoA2S-GlcNS-GlcA-pNP Protect against acetaminophen-induced liver damage
18-mer-AXa GlcNS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP Has anticoagulant activity, but no hepatoprotection effect against acetaminophen-induced liver damage
12-mer-1 GlcNS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP Protect against liver damage caused by ischemia/reperfusion damage
12-mer-3 GlcNS6S-GlcA-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA-pNP Binds to HMGB1, but has no protection against ischemia/reperfusion damage
6-mer-AXa GlcNS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S-GlcA-pNP Has anticoagulant activity but does not bind to HMGB1