Some nanobody-based tracers for non-invasive PET imaging.
| Application | Target | Nanobody | Disease model | Ref |
|---|---|---|---|---|
| Tumor biomarkers | EGFR | 7D12 | Skin cancer | 34 |
| HER2 | 2Rs15d 5F7 | Breast cancer | 33, 93 and 94 | |
| HER3 | MSB0010853 | Non-small cell lung cancer, head and neck cancer | 57 | |
| CD20 | 9079 | Non-Hodgkin lymphoma | 95 | |
| HGF | 1E6-Alb8, 6E10-Alb8 | Glioma | 96 | |
| Immune cells | CD8 | VHH-X118 | Tumor immunology and inflammatory diseases | 56 and 102 |
| CD11b | DC13 | 100 | ||
| MHC II | VHH7, VHH4 | 100 and 101 | ||
| MMR | MMR 3.49 | 98 and 99 | ||
| Checkpoint molecules | PD-L1 | B3 | PD-L1 immune checkpoint | 103 |
| CTLA-4 | H11 | CTLA-4 immune checkpoint | 104 | |
| ECM | Fibronectin EIIIB | NJB2 | Breast cancer, PDAC, and melanoma | 105 |