. 2021 May 25;6(22):14542–14550. doi: 10.1021/acsomega.1c01518

Table 1. Pharmacokinetic Parameters of HU after Oral Administration as Alone and in Combination with Rutin or Gallic Acid in Rats^a.

pharmacokinetic parameters	HU	HU + rutin	HU + gallic acid
T_1/2 (h)	0.44 ± 0.04	0.36 ± 0.12	0.45 ± 0.09
C_max (ng/mL)	21112 ± 1221	19520 ± 3355	29934 ± 4486
T_max (h)	0.30 ± 0.08	0.42 ± 0.08	0.25 ± 0.00
AUC_0–t (ng·h/mL)	23741 ± 3036	23443 ± 5169	39327 ± 5733*
AUC_0–∞ (ng·h/mL)	25441 ± 3037	25302 ± 6734	42677 ± 5870*
V_d/F (L/kg)	1.36 ± 0.34	1.02 ± 0.15	0.81 ± 0.24
CL/F (L/h/kg)	2.17 ± 0.44	2.26 ± 0.55	1.56 ± 0.26

Data are presented as mean ± SEM (n = 5). Statistical significance was evaluated by comparing treatment with HU alone versus treatment with HU in the presence of rutin or gallic acid. p < 0.05 denotes statistically significant (*).

Table 1. Pharmacokinetic Parameters of HU after Oral Administration as Alone and in Combination with Rutin or Gallic Acid in Ratsa.

Table 1. Pharmacokinetic Parameters of HU after Oral Administration as Alone and in Combination with Rutin or Gallic Acid in Rats^a.