Fig. 2. A non-extensive timeline of “hard to drug” proteins degraded with PROTACs. The insights gained from these studies will help the TPD community tackle other proteins like KRAS G12D and c-Myc. FRS2α PDB: 2MFQ; BAF PDB: 6LTJ; STAT3 PDB: 1BG1; KRAS G12C PDB: 6UTO.