Robust concentration-dependent effect of desflurane on the sum of transfer entropies calculated between primary and secondary visual cortex (V1-V2), between cortical layers 3 and 5 (L3, L5), and between various subregions. Anesthetic states 1 to 9 correspond to consecutive desflurane concentrations of 0, 2, 4, 6, 8, 6, 4, 2, 0 percent, respectively. Transfer entropy sum is in relative units, plotted as mean and 95% confidence interval. *: statistically significant quadratic trend with consecutive anesthetic states.