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. 2021 Jun 10;2021(6):CD009517. doi: 10.1002/14651858.CD009517.pub4

Comparison 1. Endometrial injury versus control.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Live birth per woman randomised (studies at low risk of selection bias and other bias) 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.12 [0.98, 1.28]
1.2 Live birth per woman randomised: sensitivity analysis (no high risk) 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.13 [0.63, 2.03]
1.3 Live birth per woman randomised: sensitivity analysis (including all studies) 29   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.4 Live birth per woman randomised: subgrouping by control exposure to endometrial manipulation 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.12 [0.98, 1.28]
1.4.1 No control exposure 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.12 [0.98, 1.28]
1.5 Live birth per woman randomised: subgrouping by RIF 8   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.5.1 Not recurrent or previous implantation failure 6   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.5.2 Recurrent or previous implantation failure 2   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.5.3 Unselected/unclear number of prior transfers 3   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.6 Live birth per woman randomised: subgrouping by timing of endometrial injury 7 3038 Odds Ratio (M‐H, Fixed, 95% CI) 1.18 [1.00, 1.38]
1.6.1 Follicular phase prior cycle 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.42 [0.67, 3.01]
1.6.2 Luteal phase prior cycle 6 2809 Odds Ratio (M‐H, Fixed, 95% CI) 1.16 [0.99, 1.37]
1.7 Live birth per woman randomised: subgrouping by intensity of endometrial injury 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.12 [0.98, 1.28]
1.7.1 Moderate intensity 7 4173 Odds Ratio (M‐H, Fixed, 95% CI) 1.11 [0.97, 1.27]
1.7.2 High intensity 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.42 [0.67, 3.01]
1.8 Live birth per woman randomised: subgrouping by timing and intensity 7 3038 Odds Ratio (M‐H, Fixed, 95% CI) 1.18 [1.00, 1.38]
1.8.1 Follicular phase prior cycle and high intensity 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.42 [0.67, 3.01]
1.8.2 Luteal phase prior cycle and moderate intensity 6 2809 Odds Ratio (M‐H, Fixed, 95% CI) 1.16 [0.99, 1.37]
1.9 Miscarriage per woman randomised (studies at low risk of selection bias and other bias) 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.68, 1.13]
1.10 Miscarriage per woman randomised: sensitivity analysis (no high‐risk) 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.17 [0.38, 3.58]
1.11 Miscarriage per woman randomised: sensitivity analysis (including all studies) 30 8092 Odds Ratio (M‐H, Fixed, 95% CI) 1.03 [0.85, 1.25]
1.12 Clinical pregnancy per woman randomised (studies at low risk of selection bias and other bias) 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.08 [0.95, 1.23]
1.13 Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.16 [0.67, 2.02]
1.14 Clinical pregnancy per woman randomised: sensitivity analysis (including all studies) 37   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.15 Clinical pregnancy per woman randomised:subgrouping by control exposure to endometrial manipulation 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.08 [0.95, 1.23]
1.15.1 No control exposure 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.08 [0.95, 1.23]
1.16 Clinical pregnancy per woman randomised:subgrouping by RIF 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.07 [0.94, 1.21]
1.16.1 Not recurrent or previous implantation failure 6 3389 Odds Ratio (M‐H, Fixed, 95% CI) 1.10 [0.95, 1.27]
1.16.2 Recurrent or previous implantation failure 2 533 Odds Ratio (M‐H, Fixed, 95% CI) 0.91 [0.63, 1.31]
1.16.3 Unselected/unclear number of prior transfers 3 480 Odds Ratio (M‐H, Fixed, 95% CI) 1.00 [0.66, 1.51]
1.17 Clinical pregnancy per woman randomised:subgrouping by timing of endometrial injury 7 3038 Odds Ratio (M‐H, Fixed, 95% CI) 1.11 [0.95, 1.29]
1.17.1 Follicular phase prior cycle 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.28 [0.62, 2.62]
1.17.2 Luteal phase prior cycle 6 2809 Odds Ratio (M‐H, Fixed, 95% CI) 1.10 [0.94, 1.29]
1.18 Clinical pregnancy per woman randomised:subgrouping by intensity of endometrial injury 8 4402 Odds Ratio (M‐H, Fixed, 95% CI) 1.08 [0.95, 1.23]
1.18.1 Moderate intensity 7 4173 Odds Ratio (M‐H, Fixed, 95% CI) 1.07 [0.94, 1.22]
1.18.2 High intensity 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.28 [0.62, 2.62]
1.19 Clinical pregnancy per woman randomised:subgrouping by timing and intensity 7 3038 Odds Ratio (M‐H, Fixed, 95% CI) 1.11 [0.95, 1.29]
1.19.1 Follicular phase prior cycle and high intensity 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 1.28 [0.62, 2.62]
1.19.2 Luteal phase prior cycle and moderate intensity 6 2809 Odds Ratio (M‐H, Fixed, 95% CI) 1.10 [0.94, 1.29]
1.20 Multiple pregnancy per woman randomised (studies at low risk of selection bias and other bias) 5 3074 Odds Ratio (M‐H, Fixed, 95% CI) 1.25 [0.80, 1.96]
1.21 Multiple pregnancy per woman randomised: sensitivity analysis (no high risk) 1 229 Odds Ratio (M‐H, Fixed, 95% CI) 0.99 [0.24, 4.06]
1.22 Multiple pregnancy per woman randomised: sensitivity analysis (including all studies) 20 5978 Odds Ratio (M‐H, Fixed, 95% CI) 1.33 [1.05, 1.68]
1.23 Pain (visual analogue scale): sensitivity analysis (including all studies) 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected