Narvekar 2010.
Study characteristics | ||
Methods | RCT, 2 arms, 100 randomised Setting: India, private fertility clinic, one centre Recruitment period: May 2007 to July 2008 |
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Participants |
Criteria relating to previous IVF failure: yes, women with at least 1 previous failure
Inclusion criteria: good responders in the previous IVF cycle (development of at least 4 good‐quality embryos); ≤ 37 years Exclusion criteria: endometrial tuberculosis in the past; intramural fibroid distorting the endometrial cavity/submucous myoma; Asherman's syndrome; evidence of hydrosalpinx |
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Interventions |
Study group: pipelle procedure conducted twice: once at the time of hysteroscopy on days 7‐10, and again on days 24‐25 (of the cycle before IVF) Control group: hysteroscopy on days 7‐10 of the cycle before IVF |
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Outcomes | Reported in paper: live birth, clinical pregnancy, miscarriage, multiple pregnancy Obtained from author correspondence: ‐ |
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Notes | Trial registration: trial does not appear to be registered Additional concerns and comments: none Funding: none stated Author correspondence: yes, undertaken with corresponding author (sachnar@rediff.com) Publication: full‐text. Numbers of previous attempts were 2.3 ± 0.52 and 2.5 ± 0.7, so the study was classified in the subgroup 'Two or more previous failures' |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random numbers were used |
Allocation concealment (selection bias) | Low risk | Sealed and consecutively numbered opaque envelopes were used |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No blinding was employed |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Only objective outcomes reported |
Incomplete outcome data (attrition bias) All outcomes | Low risk | It does not appear there was any attrition or loss to follow‐up |
Selective reporting (reporting bias) | High risk | The trial does not appear to have been registered, and important outcomes such as adverse events not reported |
Other bias | High risk | Trial not registered. |