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. 2021 Jun 10;2021(6):CD009517. doi: 10.1002/14651858.CD009517.pub4

Narvekar 2010.

Study characteristics
Methods RCT, 2 arms, 100 randomised
Setting: India, private fertility clinic, one centre
Recruitment period: May 2007 to July 2008
Participants Criteria relating to previous IVF failure: yes, women with at least 1 previous failure
Inclusion criteria: good responders in the previous IVF cycle (development of at least 4 good‐quality embryos); ≤ 37 years
Exclusion criteria: endometrial tuberculosis in the past; intramural fibroid distorting the endometrial cavity/submucous myoma; Asherman's syndrome; evidence of hydrosalpinx
Interventions Study group: pipelle procedure conducted twice: once at the time of hysteroscopy on days 7‐10, and again on days 24‐25 (of the cycle before IVF)
Control group: hysteroscopy on days 7‐10 of the cycle before IVF
Outcomes Reported in paper: live birth, clinical pregnancy, miscarriage, multiple pregnancy
Obtained from author correspondence: ‐
Notes Trial registration: trial does not appear to be registered
Additional concerns and comments: none
Funding: none stated
Author correspondence: yes, undertaken with corresponding author (sachnar@rediff.com)
Publication: full‐text.
Numbers of previous attempts were 2.3 ± 0.52 and 2.5 ± 0.7, so the study was classified in the subgroup 'Two or more previous failures'
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random numbers were used
Allocation concealment (selection bias) Low risk Sealed and consecutively numbered opaque envelopes were used
Blinding of participants and personnel (performance bias)
All outcomes High risk No blinding was employed
Blinding of outcome assessment (detection bias)
All outcomes Low risk Only objective outcomes reported
Incomplete outcome data (attrition bias)
All outcomes Low risk It does not appear there was any attrition or loss to follow‐up
Selective reporting (reporting bias) High risk The trial does not appear to have been registered, and important outcomes such as adverse events not reported
Other bias High risk Trial not registered.