Skip to main content
. 2021 Jun 10;2021(6):CD009517. doi: 10.1002/14651858.CD009517.pub4

Sherif 2018.

Study characteristics
Methods RCT, 2 arms, 60 randomised
Setting: Ain‐Shams University Hospital, Egypt ‐ one centre
Recruitment period: no description
Participants Criteria related to previous IVF failure: yes, women with previous failed ICSI were excluded
Inclusion criteria :age between 25 and 30 years old, BMI between 20 and 30, Cause of infertility either tubal causes, ovulatory causes, unexplained causes
Exclusion criteria: endometriotic patients, Male factor of infertility, Uterine cavity abnormalities, previous failed ICSI, hydrosalpinx and pyosalpinx.
Interventions Study group: single induced injury was done on the posterior endometrium 1 cm to 2 cm from the fundus by using modified Cook catheter, on day 6 of the ICSI cycle
Control group: no procedure
Outcomes Reported in paper: clinical pregnancy
Obtained by author correspondence: ‐
Notes Trial registration: PACTR201701001968212 (recruitment period unclear however stated to be conducted between 2015‐2017 on trial registry, therefore unclear whether registration was prospective or not but likely retrospective)
Additional concerns and comments: none
Funding: No description
Author correspondence: attempted but no reply received (ahmedsherif@med.asu.edu.eg)
Publication: full‐text.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Randomization was achieved by a computer generated randomization table (Research Randomizer Version 4.0 software)".
Allocation concealment (selection bias) Unclear risk No description (trial registration says opaque envelopes used, however this is not described in the paper)
Blinding of participants and personnel (performance bias)
All outcomes High risk No blinding employed
Blinding of outcome assessment (detection bias)
All outcomes Low risk Only objective outcomes reported
Incomplete outcome data (attrition bias)
All outcomes Low risk Appears to be no attrition
Selective reporting (reporting bias) Unclear risk All outcomes from trial registration page are reported, but unclear whether registration was prospective
Other bias High risk Trial does not appear to have been registered prospectively. There was a significant difference in fertilisation rate in favour of the interventional group 83 (63–100) versus 67 (47–83) in the control group (P = 0.020), which would create bias in favour of the intervention arm.