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. 2021 Jun 9;40:192. doi: 10.1186/s13046-021-01998-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Silencing of CD151 inhibits NSCLC cell proliferation, migration and invasion. a CD151 mRNA and protein levels in NSCLC cell lines which transfected with either CD151 shRNAs (sh-CD151-1 and sh-CD151-2) or negative control (sh-NC). b CCK-8 assay of cell viability in NSCLC cell lines. c Representative images of clonogenic analysis of cell proliferation in NSCLC cells. Bar charts showed clonogenic growth of NSCLC cells. d EdU incorporation assay for cell proliferation (n = 3). EdU (red), DAPI (blue). Scale bar = 200 μm. e Wound healing assay was performed to observe the role of CD151 in A549 and H1299 cells. f Representative images of the transwell assay results for cell migration and invasion in A549 and H1299 cells (sh-CD151 compared with sh-NC). β-actin was used as the internal control. Bars represent mean ± SD from three independent experiments. Significant differences compared with the control: * P < 0.05; **P < 0.01; ***P < 0.001