Fig. 7.

Adiponectin alleviated ORG in obese mice. a, Kidney tissue sections show podocytes in both groups. b-c, The body weight and blood glucose level in all animals were measured at 6, 8, 10, and 12 weeks of age). *** p < 0.001 vs. CON group, ^#p < 0.05, ^##p < 0.01 vs. HFD + gAd group. d, The serum concentrations of high-density lipoprotein, triglyceride, total cholesterol, and low-density lipoprotein were detected at 6, 8, 10, and 12 weeks of age. *** p < 0.001 vs. CON group, ^###p < 0.001 vs. HFD + gAd group. e The levels of urinary ACR and serum were assessed at various time points (6, 8, 10, and 12 weeks of age). *** p < 0.001 vs. CON group, ^###p < 0.001 vs. HFD + gAd group. f The level of serum adiponectin in mice was detected at 6 and 12 weeks of age. *** p < 0.001 vs. CON group. g-h Immunofluorescence stains of renal sections for podocin and NLRP3 at 12 weeks of age. * p < 0.05, *** p < 0.001 vs. CON group, ^###p < 0.001 vs. HFD + gAd group. Data are presented as the mean ± SEM from three independent experiments