Table 3.
Summary of the pregnancy outcomes for each treatment group
| Baseline characteristic | DP | ASMQ | AL+ | p value |
|---|---|---|---|---|
| Malaria | ||||
| Malaria before 28 weeks EGA | 97/172 (56%) | 89/169 (53%) | 96/170 (56%) | |
| Malaria before 37 weeks EGA | 165/172 (96%) | 153/169 (91%) | 162/170 (95%) | |
| Follow-up | ||||
| Followed up until ≥ 28 weeks | 91/97 (94%) | 85/89 (96%) | 92/96 (96%) | |
| Followed up until delivery | 157/172 (91%) | 152/169 (90%) | 159/170 (94%) | |
| Birth outcomes | ||||
| Twins | 1/157 (1%) | 0/152 (0%) | 2/159 (1%) | |
| Miscarriage | 1/91 (1%) | 1/85 (1%) | 1/90 (1%) | 1.00 |
| Stillbirth | 1/155 (1%) | 2/151 (1%) | 2/156 (1%) | 0.87 |
| Congenital abnormality | 2/155 (1%) | 0/151 (0%) | 3/156 (2%) | 0.38 |
| Male | 70/155 (45%) | 75/151 (50%) | 75/155 (48%) | 0.73 |
| EGA (week)* | 38.8 (1.9) | 39.0 (2.0) | 38.8 (2.1) | 0.56 |
| Preterm birth* | 13/145 (9%) | 8/135 (6%) | 14/143 (10%) | 0.45 |
| Birthweight weighed within 3 days* | 134/152 (88%) | 130/148 (88%) | 136/150 (91%) | |
| Birthweight (g)*‡ | 2860 (493) | 2926 (396) | 2881 (524) | 0.51 |
| Small for gestational age*‡ | 32/133 (24%) | 34/129 (26%) | 38/135 (28%) | 0.76 |
| Low birthweight*‡ | 28/134 (21%) | 14/130 (11%) | 26/136 (19%) | 0.06 |
| Height (cm)* | 48.8 (2.7) | 49.3 (2.6) | 49.0 (3.3) | 0.48 |
| Arm circumference (cm)* | 10.4 (1.1) | 10.5 (0.9) | 10.3 (1.2) | 0.47 |
| Head circumference (cm)* | 32.0 (1.6) | 32.2 (1.7) | 31.9 (1.8) | 0.41 |
| Apgar 5 min* | ||||
| 0–3 | 0/115 (0%) | 1/116 (1%) | 3/125 (2%) | 0.17 |
| 4–6 | 1/115 (1%) | 0/116 (0%) | 3/125 (2%) | |
| 7–10 | 114/115 (99%) | 115/116 (99%) | 119/125 (95%) | |
| Placental weight (g)* | 508 (111) | 510 (95) | 510 (121) | 0.98 |
AL+ artemether-lumefantrine extended regimen, ASMQ artesunate-mefloquine, BMI body mass index, DP dihydroartemisinin-piperaquine, EGA estimated gestational age, Pf Plasmodium falciparum, Pm Plasmodium malariae, Pv Plasmodium vivax. P value by Fisher’s exact test or ANOVA test. Figures are shown in mean (standard deviation) or number (%).
*Include only live singleton births without congenital abnormality
‡Include only those who were weighted within 3 days