Figure 8.
Four-week Aspergillus versicolor exposure results in a unique transcriptional signature in midbrain tissue. Eight week-old female B6C3F1/N mice were exposed in a nose only chamber to filtered air (FA), 3 × 105 spores of heat-inactivated Aspergillus versicolor conidia (HIC), or 3 × 105 spores of viable Aspergillus versicolor (AV) twice weekly, for 4 weeks and bulk RNA-seq analysis was performed on midbrain tissue 48H after the last exposure. Significantly enriched biological pathways were identified by GO analysis. Gene Ratio refers to the number of significant genes matched to the term/total number of significant genes (A), a Venn diagram illustrates the overlap of significantly modified genes by exposure (B), and hierarchical clustering of the differentially expressed genes, using the RNA‐seq data derived from the three exposures was assessed.