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. 2021 Jun 9;21:176. doi: 10.1186/s12866-021-02224-z

Table 5.

WhiB7 regulon genes upregulated in M. chelonae double lysogens relative to the WT M. chelonae (McProf)

MCHa gene ID Predicted function log2 FCb FDRc MABd gene ID Predicted Function
BB28_RS19005 hypothetical protein 6.1 9.1E-18 MAB_3786c Hypothetical protein
BB28_RS23100 N-acetyltransferase 5.6 4.4E-38 MAB_4621c Putative acetyltransferase
BB28_RS23095 hypothetical protein 5.2 2.8E-35 MAB_4620c Hypothetical protein
BB28_RS17590 WhiB7 transcriptional regulator 4.7 1.3E-73 MAB_3508c Putative transcriptional regulator
BB28_RS05390 GNAT family N-acetyltransferase (eis1) 4.1 5.8E-12 MAB_1125c Hypothetical acetyltransferase, GNAT family
BB28_RS06460 NAD(P)-dependent oxidoreductase 3.4 1.2E-21 MAB_1344c Putative DTDP-glucose-4,6-dehydratase-related protein
BB28_RS11540 ABC transporter ATP-binding protein 3.3 3.5E-64 MAB_2355c Putative ABC transporter ATP-binding protein
BB28_RS22650 GNAT family N-acetyltransferase (eis2) 3.3 1E-176 MAB_4532c N- acetyltransferase( eis2)
BB28_RS06750 tap multidrig efflux transporter 3.3 7.3E-35 MAB_1409c Putative drug antiporter protein precursor
BB28_RS13560 TetV Efflux Pump 3.3 9.8E-94 MAB_2780c TetV Efflux Pump
BB28_RS20470 pyridoxamine 5'-phosphate oxidase family protein 3.2 4.0E-29 MAB_4054c Hypothetical protein
BB28_RS17050 hypothetical protein 3.2 5.1E-32 MAB_3424c hypothetical protein
BB28_RS01940 N-acetyltransferase 3.0 2.9E-11 MAB_0404c Putative acetyltransferase
BB28_RS09285 ABC transporter ATP-binding protein 2.9 2.7E-07 MAB_1846 Putative ABC transporter ATP-binding protein
BB28_RS12530 18 kDa antigen (HSP 16.7) 2.3 2.5E-31 MAB_3467c 18 kDa antigen (HSP 16.7)
BB28_RS03635 EamA/RhaT family transporter 2.0 1.4E-04 MAB_0766 Hypothetical conserved integral membrane protein
BB28_RS18890 membrane protein 1.8 1.9E-17 MAB_3762 hypothetical protein
BB28_RS17595 hypothetical protein 1.8 3.6E-41 MAB_3509c Hypothetical protein
BB28_RS06440 TIGR00730 family Rossman fold protein 1.6 2.7E-08 MAB_1340 hypothetical protein
BB28_RS13900 methyltransferase domain-containing protein 1.6 1.6E-13 MAB_2845 Probable trans-aconitate methyltransferase
BB28_RS05350 hypothetical protein 1.6 2.2E-27 MAB_1117c Hypothetical protein
BB28_RS14985 GTPase HflX 1.5 8.4E-33 MAB_3042c Probable GTP-binding protein HflX
BB28_RS20665 isocitrate lyase (AceA) 1.5 3.9E-12 MAB_4095c Isocitrate lyase (AceA)
BB28_RS06230 hypothetical protein 1.5 2.7E-03 MAB_1296 hypothetical protein
BB28_RS06840 hypothetical protein 1.5 1.1E-05 MAB_1413 hypothetical protein
BB28_RS00915 cation transporter 1.5 4.6E-29 MAB_0183c Putative cation transporter
BB28_RS19745 LysE family translocator 1.5 3.7E-07 MAB_3913 Putative translocator
BB28_RS06445 TIGR00730 family Rossman fold protein 1.4 2.1E-06 MAB_1341 hypothetical protein
BB28_RS12685 aminoglycoside phosphotransferase 1.1 1.6E-02 MAB_4837c Possible phosphotransferase
BB28_RS14560 GNAT family N-acetyltransferase 1.0 2.7E-17 MAB_2959 Putative acetyltransferase

aMCH = Mycobacterium chlelonae

bLog2 Fold Change for the double lysogen (+BPs+McProf) of M. chelonae

cFDR = False Discovery Rate

dMAB = Mycobacterium abscessus