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. 2021 Jun 9;21:680. doi: 10.1186/s12885-021-08402-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Cholesterol biosynthesis genes are induced by A1542 in leukemic cells. a Diagram of cholesterol biosynthesis pathway. b RNAseq data for cholesterol biosynthesis genes after treatment of HEL for 24 h with A1542. c Level of total cholesterol in HEL cells treated with A1542 (2uM) and DMSO for 24 h. d-e Q-RT-PCR analysis of indicated genes after A1542 treatment of HEL cells for 24 h versus vehicle (DMSO)