Table 3.
Vaginal stenosis (CTCAE v3.0 scale) after 12 months (n = 142)
| Vaginal stenosis after radiotherapy | Vaginal stenosis after 12 months | Total | p-value* | ||
|---|---|---|---|---|---|
| 0 | 1 | 2 | |||
| Testosterone | p < 0.01a | ||||
| 0 | 1 (3.57%) | 6 (21.43%) | 2 (7.14%) | 9 (32.14%) | |
| 1 | 0 (0.00%) | 10 (35.71%) | 6 (21.43%) | 16 (57.14%) | |
| 2 | 0 (0.00%) | 0 (0.00%) | 3 (10.71%) | 3 (10.71%) | |
| Total | 01 (3.57%) | 16 (57.14%) | 11 (39.29%) | 28 (100.00%) | |
| Estrogen | P < 0.01b | ||||
| 0 | 1 (2.44%) | 8 (19.51%) | 0 (0.00%) | 9 (21.95%) | |
| 1 | 0 (0.00%) | 20 (48.78%) | 10 (24.39%) | 30 (73.17%) | |
| 2 | 0 (0.00%) | 1 (2.44%) | 1 (2.44%) | 2 (4.88%) | |
| Total | 1 (2.44%) | 29 (70.72%) | 11 (26.83%) | 41 (100.00%) | |
| Vaginal dilator | p = 0.372c | ||||
| 0 | 1 (3.70%) | 2 (7.41%) | 1 (3.70%) | 4 (14.81%) | |
| 1 | 1 (3.70%) | 15 (55.56%) | 4 (14.81%) | 20 (74.07%) | |
| 2 | 0 (0.00%) | 1 (3.70%) | 2 (7.41%) | 3 (11.11%) | |
| Total | 2 (7.41%) | 18 (66.67%) | 7 (25.93%) | 27 (100.00%) | |
| Lubricant gel | P < 0.01d | ||||
| 0 | 2 (4.35%) | 7 (15.22%) | 3 (6.52%) | 12 (26.09%) | |
| 1 | 0 (0.00%) | 21 (45.65%) | 9 (19.57%) | 30 (65.22%) | |
| 2 | 0 (0.00%) | 3 (6.52%) | 1 (2.17%) | 4 (8.70%) | |
| Total | 2 (4.35%) | 31 (67.39%) | 13 (28.26%) | 46 (100.00%) | |
*Symmetry test a S = 14.00; GL = 3; b S = 15.36; GL = 3; c S = 3.13; GL = 3; d S = 13.00; GL = 3