Table 1.
Correlations between D-dimer and clinicopathologic features of patients
| D-dimer < 0.55 ng/mL (n = 934) |
D-dimer ≥ 0.55 ng/mL (n = 417) |
p | |
|---|---|---|---|
| Age | 63 (58-69) | 64 (58-70) | 0.153 |
| Sex (male) | 585 (62.63%) | 263 (63.07%) | 0.878 |
| BMI, kg/m2 | 22.7 (20.8-24.4) | 22.7 (20.3-24.5) | 0.467 |
| Platelet, ×109 | 183 (148-225) | 192 (153-247) | 0.002 |
| Albumin, g/L | 39 (36-42) | 39 (36-41) | 0.089 |
| Obstructive jaundice | 301 (32.23%) | 180 (43.17%) | < 0.001 |
| NLR | 2.45 (1.87-3.28) | 2.71 (2.03-3.76) | 0.001 |
| CA19-9, U/mL | 137.3 (37.3-387.2) | 179.2 (49.0-611.4) | 0.005 |
| ASA score | 0.915 | ||
| 1 | 412 (44.11%) | 184 (44.12%) | |
| 2 | 505 (54.07%) | 224 (53.72%) | |
| 3 | 17 (1.82%) | 9 (2.16%) | |
| Comorbidity | |||
| Hypertension | 343 (36.72%) | 172 (41.25%) | 0.114 |
| Diabetes mellitus | 235 (25.16%) | 85 (20.38%) | 0.056 |
| Cardiac disease | 65 (6.96%) | 23 (5.52%) | 0.321 |
| Tumor location | 0.012 | ||
| Head | 572 (61.24%) | 285 (68.35%) | |
| Body/tail | 362 (38.76%) | 132 (31.65%) | |
| Surgical approach | 0.086 | ||
| Open | 706 (75.59%) | 333 (79.86%) | |
| Robotic | 228 (24.41%) | 84 (20.14%) | |
| Major vessel resection | 136 (14.56%) | 55 (13.19%) | 0.504 |
| Neural invasion | 798 (85.44%) | 357 (85.61%) | 0.934 |
| R1 resection, ≤ 1 mm | 114 (12.21%) | 64 (15.35%) | 0.115 |
| T stage | 0.674a | ||
| T1 | 159 (17.02%) | 64 (15.35%) | |
| T2 | 428 (45.82%) | 192 (46.04%) | |
| T3 | 120 (12.85%) | 66 (15.83%) | |
| T4 | 227 (24.30%) | 95 (22.78%) | |
| N stage | 0.521a | ||
| N0 | 487 (52.14%) | 218 (52.28%) | |
| N1 | 360 (38.54%) | 142 (34.05%) | |
| N2 | 87 (9.31%) | 57 (13.67%) | |
| Differentiation | 0.014a | ||
| Well | 361 (38.65%) | 137 (32.85%) | |
| Moderate | 422 (45.18%) | 193 (46.28%) | |
| Poor | 151 (16.17%) | 87 (20.86%) | |
| Adjuvant chemotherapy | 556 (59.53%) | 210 (50.34%) | 0.002 |
BMI, body mass index; NLR, neutrophil lymphocyte ratio; CA19-9, serum carbohydrate antigen 19-9
p value < 0.05 indicates statistical significance (in bold)
aThe chi-squared test for trend was used for the comparison of ordinal variables