Figure 5.
Representative examples of key intermolecular and intramolecular interactions. Structures shown in cartoon format with side chains as sticks. p21μ structure shown in the center in black and the area of key interactions shown in colored rectangles. hPCNA is shown in gray. Computationally modeled peptides bound to hPCNA: p21μ–pol ι, light green; p21μ–S146R, yellow; p21μ–M147I, orange; p21μ–pol δp66, purple; p21μ–PARG, red; p21μ–D149E, light blue; p21μ–Pogo, dark blue; and p21μ–FY150/151YF, dark green. Cocrystal structures of peptides bound to hPCNA: p21μ–F150Y, pink and p21μ, purple. Intramolecular hydrogen bonds are indicated as a yellow dashed line, and intermolecular hydrogen bonds are indicated as a red dashed line. Distances are indicated in angstroms. Elemental coloring: nitrogen, blue; oxygen, red; sulfur, yellow. p21, p21CIP1/WAF1; p21μ, p21 sequence 141 to 155.