Figure 7.
Computational modeling of rationally designed PIP-box peptidesp21μ–RD1, p21μ–RD2, and p21μ–RD3 on hPCNA. hPCNA shown in gray as a cartoon, with interacting amino acids shown as sticks and labeled in gray. Intermolecular polar interactions are shown as red dashed lines and intramolecular polar interactions shown as yellow dashed lines. A, overlay of the structure of the rationally designed PIP-box peptides. B, p21μ–RD1 shown in orange and conserved residues labeled. C, p21μ–RD2 shown in green and conserved residues labeled. D, p21μ–RD3 shown in pink and conserved residues labeled. p21μ, p21 sequence 141 to 155; p21, p21CIP1/WAF1.