Figure 4.

Comparison of CD97 and EMR2 in their binding with CD55.A, for comparison, structure of EMR2 (2bo2) is superimposed to the CD97 EGF domains of the complex. CD97, EMR2, and CD55 are colored pink, dark yellow, and green, respectively. Variant residues are underlined, and other key residues are shown as sticks and marked. The double-headed arrow indicates conformational change of the loop bearing key different residues between CD97 (P71) and EMR2 (L74). B and C, electronic densities around the variant residues of CD97 and their interacting residues on CD55 are shown at 2Fo − Fc of 1σ. Elements from EMR2 are also shown in panels B and C for comparison. EGF, epidermal growth factor; EMR, EGF module–containing mucin-like hormone receptor.