Figure 5.

Sequence analysis of the complemented CD97–CD55 binding mode.A, alignment of the three EGF domains within CD97. B and C, interactions of the interdomain EGF₁–EGF₂ and EGF₂–EGF₅ interfaces. D, sequence alignment of all five EGF domains of CD97. E, superposition of SCR domains of CD55. F–H, CD55 interdomain interfaces. I, sequence alignment of all four SCR domains of CD55. Color codes are shown at the top right. Interacting residues are shown as sticks and labeled, while in panels F–H, the key G193/G132/S68 residues are shown as spheres. In panels D and I, thick lines indicate disulfide bonds, while cyan and red thin lines indicate α-helices and β-strands, respectively. In panels A–D, the conserved aromatic residues and glycine residues are marked red, while in panels E–I, the structurally unconserved aromatic residues F55/F119 or hydrophilic S68 are marked cyan. EGF, epidermal growth factor; SCR, short consensus repeat.