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. Author manuscript; available in PMC: 2021 Jun 10.
Published in final edited form as: Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):54–58. doi: 10.1097/PAI.0000000000000541

FIGURE 2.

FIGURE 2.

Histologic and immunohistochemical images of PIK3CB (A), TSC (B), and mTOR (C) mutant GISTs. PIK3CB and TSC2 mutants revealed varied spindle and epithelioid (the latter shown in the figure) morphology. mTOR-mutant GIST displayed spindle cell morphology with nuclear pseudopalisading. Immunohistochemically detected KIT expression (D) exemplified by mTOR-mutant GIST was seen in all tumors. GIST Indicates gastrointestinal stromal tumor; mTOR, mammalian target of rapamycln; TSC, tuberous sclerosis complex.