FIGURE 1.
Remodeling of KCa2.1 channels associated with AF in HF patients and a porcine AF model. KCa2.1 (KCNN1) channel transcript levels were assessed in patients with paroxysmal AF (pAF; n = 10, a, b) or chronic AF (cAF; n = 10, c, d) and are displayed for left atrium (LA; a, c) and right atrium (RA; b, d) in comparison to sinus rhythm patients (SR; n = 10). (e) Mean threshold cycle (CT) levels of the housekeeping gene glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) in human left (LA) and right atria (RA) (n = 10 each). (f–i) KCa2.1 (KCNN1) mRNA levels obtained from AF pigs after 7 days (n = 5, f, g) or 14 days of atrial burst pacing (n = 5, h, i) are provided compared to respective SR controls (SR; n = 5 each). (f, g) LA, left atrium. (h, i) RA, right atrium. (j) Mean porcine GAPDH CT levels in LA and RA tissue (n = 5 each). Data are provided as box plots with underlying dots indicating original data; *p < 0.05, ***p < 0.001 versus SR controls