FIGURE 5.

Transcriptional regulation of HDACs in pig models of AF/HF. Messenger RNA expression of indicated HDACs was studied in n = 5 pigs per group exhibiting AF triggered by atrial burst pacing (AF) for 7 days (a, b) or 14 days (c, d) in comparison with corresponding control animals showing sinus rhythm (SR; n = 5 each). (a, c) LA, left atrium. (b, d) RA, right atrium. Please note that data on HDAC2 transcript levels in pigs have been published previously (Lugenbiel et al., 2021; Rahm et al., 2021). *p < 0.05, **p < 0.01 versus SR animals