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. 2021 May 27;12:582614. doi: 10.3389/fendo.2021.582614

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Copyright © 2021 Ghosh, Chen, Dill-Garlow, Ma, Yonezawa, Itoh, Rivera, Radecki, Wu, Arnold, Muller and Walker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Use of the SiRNA for Sry had similar effects in male and female FCG pups. Knockdown of Sry within the male testes was confirmed (A), but both male and female animals showed an increase in both CD4+ and CD8+ cells in the spleen as a consequence of treatment (B, C). Use of the Sry SiRNA raised expression of chordin-like 1 (D) and increased the number of double positive cells in the thymus of treated animals (E). Mouse pups were treated with the Sry or control SiRNA between days 1 and 7 postpartum before collection of tissues. Data are presented as the mean ± SD and are derived from 3 males and 11 females for control SiRNA treatment groups and 9 males and 5 females for Sry SiRNA treatment groups. Males (solid bars in B, C); Females (cross-hatched bars in B, C). Different from control SiRNA *p < 0.05; **p < 0.01.