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. 2021 May 27;12:582614. doi: 10.3389/fendo.2021.582614

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Copyright © 2021 Ghosh, Chen, Dill-Garlow, Ma, Yonezawa, Itoh, Rivera, Radecki, Wu, Arnold, Muller and Walker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of testosterone and estradiol on cell numbers in the spleen. FCG Mouse pups were treated between days 1 and 7 postpartum before collection of tissues. Data are derived from gated lymphocytes, presented as the mean ± SD, and are derived from 6 males and 5 females in the control group, 3 males and 3 females in the testosterone group and 5 males and 7 females in the estradiol group. S, sesame oil control; T, testosterone; E, estradiol. Males include both XYM and XXM (solid bars) and females include both XXF and XYF (cross-hatched bars). Different from same sex control *p < 0.05, effect size 2.3 and 2.0 for CD4+ and CD8+ cells, respectively.