TABLE 1.
Primary information on the PDGFRA rs6554163 T > A, RASGRF1 rs6495367 G > A, PTPN5 rs1550870 C > T, PTPRR rs11178469 T > C polymorphisms.
Control group vs. incident myopia group |
Control group vs. significant myopic shift group |
|||||||
Gene | SNP | MAFa for the Chinese populationb | Call rate (%) | MAFa in our controls (n = 174) | P-value for the HWEc test in our controls | MAFa in our controls (n = 281) | P-value for the HWEc test in our controls | P-value in GWAS |
PDGFRA | rs6554163 T > A | 0.221 | 99.10 | 0.21 | 0.259 | 0.20 | 0.266 | 2.8 × 10–6 (Guggenheim et al., 2013) |
RASGRF1 | rs6495367 G > A | 0.490 | 98.58 | 0.49 | 0.546 | 0.48 | 0.340 | 1.95 × 10–24 (Tedja et al., 2018) |
PTPN5 | rs1550870 C > T | 0.296 | 98.82 | 0.27 | 0.570 | 0.27 | 0.176 | 9.9 × 10–13 (Pickrell et al., 2016) |
PTPRR | rs11178469 T > C | 0.394 | 99.13 | 0.41 | 1 | 0.41 | 0.622 | 1.33 × 10–13 (Tedja et al., 2018) |
aMinor allele frequency. bRefer to https://www.internationalgenome.org/category/dbsnp. cHardy-Weinberg equilibrium.