TABLE 4.
Distribution of genotypes and alleles of SNPs in the control and incident myopia groups.
| Incident myopia group (n = 202) |
Control group (n = 174) |
|||||||
| SNP | Genotype | No. | % | No. | % | OR (95% CI)c | Pa | Pb |
| PDGFRA rs6554163 T > A | ||||||||
| Additive | AA/TA/TT | − | − | − | − | 0.713 (0.462, 1.099) | 0.125 | 0.124 |
| Dominant | TT | 135 | 66.8 | 105 | 60.3 | Ref. | ||
| TA + AA | 67 | 33.2 | 69 | 39.7 | 0.639 (0.390, 1.046) | 0.075 | 0.073 | |
| Recessive | TA + TT | 196 | 97.0 | 169 | 97.1 | Ref. | ||
| AA | 6 | 3.0 | 5 | 2.9 | 1.046 (0.280, 3.906) | 0.947 | 0.959 | |
| RASGRF1 rs6495367 G > A | ||||||||
| Additive | AA/GA/GG | − | − | − | − | 0.959 (0.685, 1.344) | 0.809 | 0.808 |
| Dominant | GG | 44 | 21.8 | 47 | 27.0 | Ref. | ||
| GA + AA | 158 | 78.2 | 127 | 73.0 | 0.832 (0.472, 1.467) | 0.526 | 0.533 | |
| Recessive | GA + GG | 147 | 72.8 | 130 | 74.7 | Ref. | ||
| AA | 55 | 27.2 | 44 | 25.3 | 1.060 (0.622, 1.807) | 0.830 | 0.836 | |
| PTPN5 rs1550870 C > T | ||||||||
| Additive | TT/CT/CC | − | − | − | − | 1.454 (0.961, 2.199) | 0.076 | 0.077 |
| Dominant | CC | 83 | 41.1 | 91 | 52.3 | Ref. | ||
| CT + TT | 119 | 58.9 | 83 | 47.7 | 1.885 (1.152, 3.086) | 0.012 | 0.011 | |
| Recessive | CT + CC | 191 | 94.6 | 163 | 93.7 | Ref. | ||
| TT | 11 | 5.4 | 11 | 6.3 | 0.634 (0.229, 1.753) | 0.380 | 0.371 | |
| PTPRR rs11178469 T > C | ||||||||
| Additive | CC/TC/TT | − | − | − | − | 0.993 (0.699, 1.410) | 0.969 | 0.970 |
| Dominant | TT | 71 | 35.1 | 61 | 35.1 | Ref. | ||
| TC + CC | 131 | 64.9 | 113 | 64.9 | 1.106 (0.672, 1.821) | 0.692 | 0.692 | |
| Recessive | TC + TT | 173 | 85.6 | 145 | 83.3 | Ref. | ||
| CC | 29 | 14.4 | 29 | 16.7 | 0.817 (0.421, 1.583) | 0.549 | 0.551 | |
aAdjusted for age, sex, near-work time, outdoor time, and baseline SE. bAdjusted for age, sex, near-work time, outdoor time, and baseline SE with 10,000 permutations. cCI, confidence interval. The bold values are P < 0.05.