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. 2021 May 27;12:654869. doi: 10.3389/fgene.2021.654869

TABLE 6.

Associations of SNPs with quantitative ocular traits in different genetic models.

Additive
 Dominant
 Recessive
Variable SNP βa (95% CI) Pa Pb βa (95% CI) Pa Pb βa (95% CI) Pa Pb
Δ SE, D/y PDGFRA rs6554163 0.018 (−0.056, 0.091) 0.638 0.634 0.022 (−0.062, 0.106) 0.607 0.606 0.007 (−0.229, 0.243) 0.956 0.958
RASGRF1 rs6495367 0.061 (0.004, 0.117) 0.036 0.037 0.114 (0.019, 0.210) 0.019 0.019 0.051 (−0.039, 0.141) 0.266 0.265
PTPN5 rs1550870 −0.055 (−0.122, 0.012) 0.107 0.117 −0.080 (−0.162, 0.002) 0.056 0.055 −0.011 (−0.174, 0.152) 0.898 0.896
PTPRR rs11178469 0.009 (−0.052, 0.069) 0.779 0.774 −0.008 (−0.094, 0.078) 0.856 0.857 0.044 (−0.069, 0.157) 0.444 0.439
Δ AL, mm/y PDGFRA rs6554163 0.012 (−0.015, 0.038) 0.394 0.402 0.010 (−0.020, 0.040) 0.524 0.523 0.042 (−0.045, 0.129) 0.349 0.351
RASGRF1 rs6495367 −0.018 (−0.038, 0.003) 0.092 0.089 −0.035 (−0.069, −0.001) 0.046 0.047 −0.013 (−0.045, 0.019) 0.430 0.436
PTPN5 rs1550870 0.023 (−0.001, 0.047) 0.060 0.056 0.033 (0.004, 0.063) 0.025 0.025 0.004 (−0.053, 0.062) 0.878 0.880
PTPRR rs11178469 −0.007 (−0.029, 0.014) 0.520 0.522 0.003 (−0.028, 0.033) 0.861 0.862 −0.030 (−0.070, 0.011) 0.149 0.148
Δ CRC, mm/y PDGFRA rs6554163 −0.002 (−0.005, 0.002) 0.350 0.351 −0.002 (−0.005, 0.002) 0.360 0.362 −0.002 (−0.013, 0.009) 0.694 0.695
RASGRF1 rs6495367 0.000 (−0.002, 0.003) 0.739 0.733 0.000 (−0.005, 0.004) 0.875 0.875 0.001 (−0.003, 0.005) 0.498 0.507
PTPN5 rs1550870 0.001 (−0.002, 0.004) 0.585 0.578 0.000 (−0.004, 0.004) 0.998 0.997 0.005 (−0.002, 0.012) 0.188 0.184
PTPRR rs11178469 −0.001 (−0.004, 0.001) 0.314 0.321 −0.002 (−0.006, 0.002) 0.339 0.340 −0.002 (−0.007, 0.003) 0.533 0.529
Δ CCT, mm/y PDGFRA rs6554163 0.233 (−0.118, 0.584) 0.194 0.196 0.254 (−0.144, 0.652) 0.211 0.216 0.360 (−0.762, 1.481) 0.530 0.502
RASGRF1 rs6495367 0.042 (−0.230, 0.313) 0.763 0.767 0.142 (−0.318, 0.602) 0.546 0.549 −0.019 (−0.448, 0.410) 0.931 0.933
PTPN5 rs1550870 −0.350 (−0.668, −0.032) 0.032 0.033 −0.460 (−0.849, −0.071) 0.021 0.019 −0.246 (−1.018, 0.526) 0.533 0.518
PTPRR rs11178469 −0.127 (−0.415, 0.160) 0.386 0.384 −0.174 (−0.582, 0.234) 0.404 0.400 −0.144 (−0.685, 0.397) 0.602 0.600
Δ LT, mm/y PDGFRA rs6554163 −0.029 (−0.071, 0.014) 0.190 0.187 −0.053 (−0.101, −0.004) 0.033 0.033 0.127 (−0.009, 0.263) 0.069 0.075
RASGRF1 rs6495367 −0.004 (−0.037, 0.028) 0.795 0.797 −0.046 (−0.101, 0.010) 0.106 0.109 0.029 (−0.023, 0.081) 0.272 0.280
PTPN5 rs1550870 0.040 (0.001, 0.079) 0.043 0.041 0.046 (−0.001, 0.093) 0.057 0.056 0.054 (−0.039, 0.148) 0.255 0.255
PTPRR rs11178469 −0.031 (−0.066, 0.004) 0.084 0.080 −0.048 (−0.097, 0.001) 0.056 0.054 −0.024 (−0.090, 0.042) 0.478 0.484
Δ ACD, mm/y PDGFRA rs6554163 −0.014 (−0.033, 0.006) 0.167 0.175 −0.009 (−0.031, 0.012) 0.404 0.411 −0.065 (−0.126, −0.004) 0.038 0.091
RASGRF1 rs6495367 0.011 (−0.004, 0.025) 0.162 0.170 0.006 (−0.019, 0.031) 0.638 0.647 0.021 (−0.002, 0.045) 0.076 0.066
PTPN5 rs1550870 0.000 (−0.017, 0.018) 0.966 0.967 −0.006 (−0.027, 0.016) 0.608 0.627 0.024 (−0.018, 0.066) 0.266 0.243
PTPRR rs11178469 −0.006 (−0.022, 0.010) 0.452 0.454 −0.003 (−0.026, 0.019) 0.772 0.786 −0.016 (−0.045, 0.014) 0.303 0.256

βa is the coefficient of linear regression indicating the sizes of effects on changes in SE, AL, CRC, CCT, LT, and ACD during the 3.5-year follow-up. Pa, adjusted for age, sex, near-work time, outdoor time, and the baseline of each outcome indicator (baseline SE for ΔSE, baseline AL for ΔAL, baseline CRC for ΔCRC, baseline CCT for ΔCCT, baseline LT for ΔLT and baseline ACD for ΔACD). Pb, adjusted for age, sex, near-work time, outdoor time, and baseline of each outcome indicator with 10,000 permutations. The bold values are P < 0.05.