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GEMMs of Breast Cancer.
| Promoter | Activator | Mammary oncogene | Latency (week) | Metastasis |
|---|---|---|---|---|
| MMTV-LTR | Steroid hormones | neu/ErbB2 gene PyMT viral oncogene Cyclin D1 gene Myc gene Wnt1 gene |
30 4–8 88 16–76 32 |
Lungs Lungs & lymph nodes Non-metastatic Non-metastatic Non-metastatic |
| WAP | Lactogenic hormones | Ras gene | 24 | Lungs |
| C(3)1 | Estrogen | SV40 Tag viral oncogene | 21 | Lungs & lymph nodes |
| P53 null “T11” | Steroid hormones | p53 | 24–48 | Peritoneal cavity |
(Adapted from [214])
