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. 2021 May 27;12:688808. doi: 10.3389/fgene.2021.688808

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Copyright © 2021 Hoffmann, Roeth, Diebold, Gogel, Hassel, Just and Rappold.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Database analyses of SHOX-regulated genes. (A) Network-based pathway analysis of SHOX-regulated genes using the Ingenuity pathway analysis (IPA) software. SHOX is highlighted in red. Known SHOX-associated genes are shown in yellow. Novel SHOX-regulated genes are shown in gray. Direct regulations are indicated by arrows and interactions as lines; indirect regulations or interactions are presented as dotted arrows/lines, respectively. The most important annotated pathways relevant to SHOX-associated diseases or function are highlighted in green (genes involved in growth failure and short stature) and blue (genes involved in limb defects). (B) Gene-disease association according to DisGeNET. Venn diagram showing associations between SHOX and 23 SHOX-regulated genes with respect to skeletal phenotypes based on the DisGeNET database (https://www.disgenet.org/home/; Pinero et al., 2015).