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. 2021 May 21;12:640347. doi: 10.3389/fphar.2021.640347

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Copyright © 2021 Liu, Liao, Zhang, Sun, Luo, Chen, Li, Lu and Ying.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metformin prevents DSS-induced colitis in mice. C57BL/6 mice were divided into five groups and induced acute colitis by giving 3% DSS. The mice were treated with intraperitoneal PBS or metformin (150 mg/kg/day) daily. (A) The body weight changes during the colitis induction process. Significance was tested by Two-way ANOVA. *p < 0.05 ****p < 0.0001, n = 8. (B) The colon length of each group. The Significance was analyzed by student t-test (mean ± SEM, n = 8), **p < 0.01, ***p < 0.001. (C) The representative macroscopic image of mice colon. (D) Histology analyzed the severity of colitis in DSS with H&E staining. Representative images are shown. Overview: 100 ×; magnification: 400 ×, Scale bar = 100 µm and 20 µm.